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434 microbial strains found in Purulent Osteology Department patients were analyzed. 203 infectious agents were found in patients with purulence after major joint prosthetics, 148 - in patients with chronic osteomyelitis, 83 - in diabetic foot patients. Grampositive microorganisms accounted for 302 strains, gram-negative ones - for 132 strains. Irrespective of nosology, main infectious agents were represented by various staphylococci, a third of which expressed mec A gene displaying a phenotype of methicillin-resistant strains. Ps. Aeruginosa was second in detection rate, among which 9 strains out of 51 had a gene encoding VIM-type Metallo-beta-lactamase production. The third place in detection rate belonged to A. baumanii. 15 strains producing OХА-40-like carbapenemases were found among 29 acinetobacter isolates. 14 out of 19 K. pneumoniae strains produced extended spectrum beta-lactamases. Therefore, similar patterns in infectious agent structure were found in Purulent Osteology Department patients with various infectious processes: staphylococci predominance and circulation of a great number of antibiotic multiresistant microorganisms. A thorough microbiological monitoring enables determining of phenotype and genotype of antibiotic resistance and prescribing a balanced antimicrobic therapy.

THE VALUE OF MICROBIOLOGICAL MONITORING AND DETERMINING THE MOLECULAR GENETIC CHARACTERISTICS OF HOSPITAL MICROFLORA OF PURULENT OSTEOLOGY DEPARTMENT