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In the study, the state of the vitreoretinal interface (VRI) was investigated in diabetic macular edema (DME) at primary diagnosis and during regular antiangiogenic ranibizumab therapy. At primary diagnosis, pathological VRI changes were detected in 49.3% of cases. During regular antiangiogenic therapy, the transformation of initially normal VRI into pathological one occurs in 6% of cases, the transformation of initially pathological VRI into normal or other pathological one – in 15.8%. Initially pathological VRI is not an absolute indication for vitrectomy, since in no fewer than 7.9% of cases its transformation into normal VRI is possible.

Dynamics of vitreoretinal interface changes in diabetic macular edema during regular antiangiogenic therapy