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Background. Nowadays, laser surgery methods for glaucoma treatment gained wide use in clinical practice due to their efficacy, safety, and minimal risk of postoperative complications. In the scientific literature, data are presented on the effect of laser radiation on corneal endothelial cells that is why this aspect should be investigated when using new laser technologies in glaucoma treatment. One of the most modern methods of corneal examination is confocal microscopy, which allows visualizing corneal tissue at cellular level. Purpose: to study the impact of laser radiation on the state of corneal endothelial cells in YAG-laser activation of trabecular meshwork in patients with primary open-angle glaucoma. Materials and methods. Sixteen eyes of 15 patients were included in the analysis. The mean age of patients was 65.8 ± 5.35 years. In all patients, YAG-laser activation of trabecular meshwork was performed. At different follow-up terms (up to 6 months after laser surgery) the level of IOP was controlled, the state of corneal endothelium was studied using confocal microscopy. Results. According to dynamic follow-up confocal microscopy results, no statistically significant difference between average density of endothelial cells, polymegathism, and pleomorphism have been identified ( p > 0.05). Conclusion. The study did not reveal any negative impact of YAG-laser activation of trabecular meshwork on the endothelium of the cornea, suggesting the safety of this technology.

Сorneal endothelium after laser activation of trabecular meshwork in patients with primary open-angle glaucoma