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Aim — to reveal the connection between the initial morphofunctional characteristics of patients and the dynamics of changes in the diastolic function at the time of, as well as during 6 months of observation after the episode of acute decompensated heart failure against the background of standard therapy and with adding the If-channel blocker ivabradine. Material and methods . We examined 127 patients hospitalized with the episode of the acute decompensated heart failure with a sinus rhythm and heart rate more than 85 beats per minute. Among them 67 patients received ivabradine in addition to standard therapy, 60 patients were in control group. A 6-minute walk test, echocardiography assessment of systolic and diastolic function, electrocardiography (heart rate and rhythm) were performed on the day of admission (except for the 6-minute walk test), in 1 and 6 months later. Results . A scoring of the chance for positive dynamics of diastolic function was obtained in patients with acute decompensated heart failure, in the presence of certain initial characteristics of patients, such as: systolic pulmonary artery pressure 50% ( p 0,46 ( p < 0.005), female. A relationship between improvement in diastolic function and improvement in results of 6-minute walk test was found: with a positive dynamics of diastolic function, patients began to walk a distance in the 6-minute walk test by 6,9 ± 2,9 meters more ( p < 0.0005). Conclusion . The data obtained in our study confirm the advisability of adding ivabradine to the standard therapy of patients with acute decompensated heart failure with the determined “useful” morphofunctional characteristics.

Model of evaluation of the dynamics of left ventricular diastolic function in acute decompensated heart failure. Effect of ivabradin