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Using multicolor flow cytometry four main Th17 subsets were identified within total CCR6-expressing Th cell in peripheral blood from patients with multiply sclerosis (MS, n = 26) and healthy control subjects (HC, n = 44). MS showed significantly higher frequencies of CCR6+DP and “classical” Th17 subsets, while the level of Th17.1 was significantly decreased if compared to HC. Correlation analysis revealed a significant relationship between the decrease of CCR6+DN Th17 subset and EDSS worsening (r = –0.456, p = 0.022). The area under the ROC curve (AUC) for the percentage of “classical” Th17 within CCR6+ Th as a predictor of MS was 0.948 (0.882 to 1.014, p < 0.001) and for Th17.1 cells — 0.937 (0.863 to 1.011, p < 0.001). The optimal cutoff value for percentage of “classical” Th17 for predicting MS was 31.55% within CCR6+ Th cells with 88.0% sensitivity and 95.45% specificity, while for Th17.1 — 38.66% within CCR6+ Th cells with 88.0% sensitivity and 95.45% specificity. Our data indicate that the relative numbers of “classical” Th17 and Th17.1 within CCR6+ Th cells were effective in discrimination between MS and HC groups.

PERIPHERAL BLOOD TH17 SUBSETS IN PATIENTS WITH MULTIPLE SCLEROSIS