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Aim. To determine the effect of ozone on blood coagulation system and to develop the tactics of treatment of patients with acute gastroduodenal ulcerative bleedings in order to prevent postoperative complications. Methods. Analyzed were the results of treatment of 328 patients (males) with acute gastroduodenal ulcerative bleedings who were treated at the department of emergent surgery of the Veterans Hospital of Kazan during the period of 2005-2009. Ozone therapy was used in the complex treatment in 66 patients of the main group with acute gastroduodenal ulcerative bleedings. The comparison group included 262 patients who underwent complex treatment according to the traditional scheme. Electronic coagulography machine was used to assess the effects of ozone on blood coagulation. Results. Tissue oxygenation improved after transfusion of the erythrocyte mass treated with ozone, which significantly reduced the progression of necrotic ulcer. The use of ozone therapy in patients with this pathology has led to a decrease in postoperative mortality from 24.7 to 16.7%. Conclusion. The use of ozone following this technique in the complex treatment of patients with acute gastroduodenal ulcerative bleedings is an important component of prevention of a myocardial infarction, acute ischemic attacks and thrombotic disorders.

Ozonized erythrocyte mass in the treatment of patients with ulcerative gastroduodenal bleedings