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Aim. To evaluate the reaction of hemostatic system in rats on various duration of the intake of concentrated product containing blood and histolysate of Siberian stag reproductive organs, and to exclude the possible adaptive effect of additives (glucose, ascorbinic acid, fruit essences), contained in the used concentrate, on hemostatic system. Methods. The study included 50 mature male Wistar rats. Three groups of experimental animals, including 10 rats each, received the concentrate containing blood and histolysate of the Siberian stag reproductive organs in the dose of 4.5 ml per day for 7, 14 and 30 days. Parameters obtained from the experimental animals were compared to those from intact rats and control group, receiving only additives, contained in the used concentrate. Results. On day 7 of concentrate administration, the hemostatic parameters did not differ from those of intact rats. After 14 days of concentrate administration, decrease of fibrinogen concentration in blood and increase of anticoagulant activity of blood plasma were observed. On day 30 of concentrate intake, in addition to the earlier revealed changes in hemostatic system, hypocoagulation in the intrinsic pathway of plasma hemostasis activation and also increase of fibrinolytic activity of blood plasma were registered. Upon the expiration of 30 days of administration of additives, contained in the studied product, hemostatic parameters of the animals from the control group did not differ from those of intact rats. Conclusion. Increase of adaptation of hemostatic system when taking the studied concentrate apparently involves increase of anticoagulant and fibrinolytic activity of rat blood plasma and reduction of fibrinogen concentration in the blood; the active component providing adaptive changes in the hemostatic system is the complex of biologically active substances contained in the blood and histolysate of the Siberian stag reproductive organs.

Increase of anticoagulant and fibrinolytic activity of rat blood plasma when using products of velvet antler industry