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Adenosquamous carcinoma (ASC) is a rare type of squamous cell carcinoma (SCC) composed of two independent histologic components. The squamous component begins at the mucosal epithelium with definite evidence of dysplastic squamous epithelium progressing to SCC. The glandular component locates deep under the squamous component. Glandular component is characterized by a true glandular pattern with mucous, but must not originate from salivary glands or other normal glandular structures. ASC has a predilection for males and elder patients. Most of the case reported of oral ASC occurred in the mouth floor, with a few reports arising in the tongue, palate and mandible. In this case report, we described a rare case of ASC arising at the buccal mucosa which was first misdiagnosed as general SCC.

Adenosquamous Carcinoma at the Buccal Mucosa