POLG1/ANT1-Related SANDO is a Multisystem Mitochondrial Disorder

Published by United Scientific Group In a recent article Kirschenbaum et al., described a 50 years female with sensory ataxic neuropathy with dysarthria and ophthalmoplegia (SANDO) syndrome due to the mutation c.467A>T in the POLG1 gene [1]. SANDO, first described by Fadic et al. in 1997 [2], is clinically characterized by the triad of sensory ataxic neuropathy, dysarthria, and ophthalmoparesis [3]. We have the following comments and concerns.