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Aim: According to current biopsychiatric models, hypomania is associated with subvigil patterns in EEG, suggesting a significant impact of instable vigilance dynamics to bipolar disorders. Quetiapine as a well-accepted treatment option in bipolar disorders has been suggested to modify vigilance regulation by its high affinity to 5HT1A receptors at raphe nucleus, so even a low dose administration of quetiapine might be quite efficient to guide the recovery of the presumed instable vigilance dynamic in hypomanic state of bipolar disorder.

Efficacy of Low Adjunctive Quetiapine Administration in Control of Hypomanic State in Bipolar Affective Disorder Captured by EEG