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espanolIntroduccion El trastorno depresivo mayor (TDM) es una enfermedad prevalente a nivel mundial, que afecta mas a mujeres que a hombres. En la genesis de la depresion se consideran diversos factores, entre ellos algunas hormonas como la testosterona y ciertos factores metabolicos Objetivo Evaluar los niveles de hormonas y variables metabolicas en mujeres con depresion mayor y controles sanas. Metodo Se realizo un estudio transversal, comparativo y analitico en 40 participantes, 23 pacientes con diagnostico de TDM y 17 controles, todas ellas mujeres de 18 a 45 anos en periodo reproductivo. Se evaluaron variables sociodemograficas, perfil hormonal y variables metabolicas, y se aplico la Escala de Depresion de Hamilton de 17 reactivos para evaluar los sintomas depresivos. Resultados No se observaron diferencias estadisticamente significativas entre los grupos en las variables hormonales y metabolicas exploradas. Sin embargo, se observo que, cuanto menores eran los niveles de testosterona y mayores los de glucosa serica, los sintomas depresivos eran de mayor intensidad. Discusion y conclusion La testosterona se asocia con un menor puntaje de sintomas depresivos en la Escala Hamilton, lo que sugiriere un potencial efecto antidepresivo, mientras que los niveles altos de glucosa se asocian con un mayor puntaje en dicha escala. Consideramos que la medicion de variables hormonales y metabolicas en la mujer puede contribuir a mejorar el conocimiento de la fisiopatologia de la depresion. EnglishIntroduction: major depressive disorder (MDD) is a prevalent disease affecting women more than men worldwide. Various factors are involved in the genesis of depression, including hormones such as testosterone and certain metabolic factors Objective: to evaluate hormone levels and metabolic variables in women with major depression and healthy controls. Method: a cross-sectional, comparative analytical study was conducted in 40 participants, 23 patients with an MDD diagnosis and 17 controls, all of women in reproductive age between the ages of 18 and 45. Sociodemographic variables, hormonal profile, and metabolic variables were assessed and the 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Results: no statistically significant differences were observed between the groups in the hormonal and metabolic variables explored. Nevertheless, it was observed that the lower the testosterone levels and the higher the serum glucose levels, the more intense depressive symptoms were. Discussion and conclusion: testosterone is associated with a lower depressive symptoms score on the Hamilton Depression scale, suggesting a potential antidepressant effect, whereas high glucose levels are associated with a higher score on this scale. We believe that the measurement of hormonal and metabolic variables in women can contribute to a better understanding of the pathophysiology of depression.

Evaluation of hormonal and metabolic factors related to depression in reproductive age women