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espanolIntroduccion El estres durante la pubertad ejerce efectos a largo plazo sobre sistemas endocrinos y estructuras cerebrales como corteza prefrontal (CPF) y amigdala basolateral (ABL). Ambas estructuras participan en la modulacion de la conducta sexual y su funcionamiento es regulado por androgenos. Objetivo Evaluar los efectos del estres puberal por aislamiento social sobre la motivacion sexual, los niveles sericos de testosterona y la actividad electroencefalografica (EEG) de la CPF y ABL en ratas macho. Metodo Se utilizaron sesenta ratas macho sexualmente expertas, 30 fueron estresadas por aislamiento social durante la pubertad (GE, hospedados 1 por caja, dias 25 al 50 postnatal), y el resto conformo el grupo control (GC, hospedados 5 por caja). Las ratas fueron implantadas bilateralmente en la CPF y ABL y el EEG fue registrado durante estado vigilia-quieto en dos condiciones: sin motivacion sexual (SMS) y con motivacion sexual (MS). Finalmente, las ratas se sacrificaron por decapitacion para medir los niveles de testosterona. Resultados El GE presento menor motivacion sexual, menores niveles de testosterona y, en presencia de una hembra receptiva, presentaron una mayor activacion EEG amigdalina, mientras que el GC mostro una mayor activacion EEG prefrontal. Discusion y conclusion Es probable que la disminucion de los niveles de testosterona como resultado del estres puberal haya afectado la funcionalidad prefrontal y amigdalina y, por ende, la motivacion sexual. Estos datos pudieran explicar algunos de los cambios hormonales y cerebrales asociados con alteraciones sexuales producidas por estres. Esta propuesta debera explorarse en futuras investigaciones animales y clinicas. EnglishIntroduction: stress during puberty exerts long-term effects on endocrine systems and brain structures, such as the prefrontal cortex (PFC) and basolateral amygdala (BLA), two cerebral areas that participate in modulating sexual behavior and whose functioning is regulated by androgenic hormones. Objective: to evaluate the effect of pubertal stress due to social isolation on the sexual motivation, serum testosterone levels, and electroencephalographic activity (EEG) of the PFC and BLA in male rats. Method: sixty sexually-experienced male rats were used. Thirty were stressed by social isolation during puberty (SG, housed 1 per cage, postnatal days 25-50); the other 30 formed the control group (CG, 5 per cage). All rats were implanted bilaterally with stainless steel electrodes in the PFC and BLA. EEGs were recorded during the awake-quiet state in two conditions: without sexual motivation (WSM), and with sexual motivation (SM). After EEG recording, the rats were sacrificed by decapitation to measure their testosterone levels. Results: SG showed lower sexual motivation and testosterone levels, but higher amygdaline EEG activation in the presence of a receptive female, while CG showed higher prefrontal EEG activation. Discussion and conclusion: It is probable that the decreased testosterone levels resulting from pubertal stress affected prefrontal and amygdaline functionality and, hence, sexual motivation. These data could explain some of the hormonal and cerebral changes associated with stress-induced sexual alterations, though this suggestion requires additional clinical and animal research.

Electroencephalographic changes and testosterone levels in a pubertal stress animal model: effects on adult sexual motivation