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SUMMARY The presence of a psychiatric disorder in parents is associated with increased frequency of psychopathology in their offsprings. Children of parents diagnosed with bipolar disorder (BD) are at greater risk and lower function. However, it has not yet been determined precisely which clinical and sociodemographic factors are associated with the presentation of psychiatric disorders in this group of children and ado- lescents at risk. Under this framework, the aim of this study was to de- termine the clinical and sociodemographic variables associated with a lower function. We recruited 61 children and adolescents with ages ranging from six to 17. All of them were the children of parents with BD who were patients attended at the National Institute of Psychiatry Ramon de la Fuente Muniz. Clinical evaluation was developed by the Kiddie Schedule for Affective Disorders and Schizophrenia for School- Age Children Present and Lifetime Version (K-SADS-PL), and Childrens Global Assesment Scale (C-GAS) scale was used to established the overall functioning. Of the 61 evaluated 62.3% were women, the lowest function (defined by <81 points C-GAS) was found in 44.3% of women vs. 18% men (χ 2 =3.2, p<0.043). Comorbidity with major depressive disorder or attention deficit hyperactivity disorder or op- positional defiant disorder conferred ten times greater risk of lower global function. Being a woman gives three times higher risk for a lower global function.

Asociación de comorbilidades y funcionamiento global en hijos de padres con trastorno bipolar