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Pemphigus vulgaris is an autoimmune disease characterized by ulcerative and bullous lesions on skin and mucous membranes. The aim of this paper is to report a case of oral pemphigus vulgaris, emphasizing the treatment and discuss some clinical and histopathologic features of this disease. Case Report: The patient is a 38year-old male, feodermic, who was referred to a specialized service in oral diagnosis in the city of João Pessoa – Paraíba State, complains of multiple ulcerative lesions in the oral cavity, dysphagia, dysphonia, and marked weight loss. The diagnostic hypotheses were pemphigus vulgaris and mucous membrane pemphigoid. An incisional biopsy was performed on buccal mucosa and the diagnosis of the pemphigus vulgaris was made. Initially, the treatment of choice was systemic administration of prednisone 80 mg. In the first weeks, a remission of the oral lesions occurred. The dosage was gradually reduced to the current dose of 2.5 mg/day. Conclusion: Treatment was effective, once there was remission of all oral lesions. Descriptors: Pemphigus; Treatment; Diagnosis; Mouth Mucosa. Introdução O pênfigo representa um grupo de doenças autoimunes e incomuns que se caracterizam pela presença de lesões bolhosas e ulceradas na pele e em mucosas(1). O termo “pênfigo” geralmente engloba quatro subtipos: vulgar, vegetante, eritematoso e foliáceo. Desses, o primeiro se destaca na Odontologia em razão da maior prevalência de acometimento da cavidade oral (aproximadamente 70%). A doença é mais comum em indivíduos de meia idade e não há predileção por sexo(1-2). As lesões do pênfigo vulgar (PV) se desenvolvem em virtude de uma alteração no sistema imunológico do paciente, no qual ocorre a produção de autoanticorpos contra a desmogleína 1 e 3, proteínas encontradas nos desmossomos que auxiliam na adesão das células epiteliais. As lesões orais de PV, normal-

EFICÁCIA DO USO DE CORTICOSTEROIDE SISTÊMICO NO TRATAMENTO DO PÊNFIGO VULGAR ORAL