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| A 6 year old male castrated Cavalier King Charles Spaniel presented to the Louisiana State University Veterinary Teaching Hospital for a three day history of bilateral acute trismus, exophthalmos, and blindness. These signs developed after an exploratory laparotomy and gastrointestinal foreign body removal was performed. On presentation, the ophthalmic examination revealed bilateral decreased retropulsion, absent bilateral direct and consensual pupillary light responses, bilateral blindness, and a superficial ulcer in right eye. Ocular ultrasound and computed tomography of the skull were performed and identified a bilateral retrobulbar mass effect originating from the zygomatic salivary glands. Ultrasound guided fine needle aspirate cytology revealed neutrophilic inflammation. Fungal testing and bacterial cultures were performed which were negative for identification of an infectious organism. The patient was placed on a 5-day course of antibiotic therapy and the response was poor. Phenobarbital was added to the treatment regimen. Two days following phenobarbital administration, the exophthalmos and trismus began to resolve. Following phenobarbital therapy, ocular position normalized, trismus completely resolved, and patient returned to normal behavior although blindness remained in both eyes. No other neurologic condition occurred. This paper highlights the early use of phenobarbital for the rapid resolution of zygomatic sialadenitis.

Phenobarbital-Responsive Bilateral Zygomatic Sialadenitis following an Enterotomy in a Cavalier King Charles Spaniel