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| The aim of this study was to assess the preventive effects of Ulva fasciata (U. fasciata) ethanolic extract and silver nanoparticles (AgNPs) biosynthesized by this extract against nephrocardiototoxicity caused by doxorubicin in male Wistar rats. Biosynthesized AgNPs were also characterized and the constituents of U. fasciata ethanolic extract were identified. To assess the renocardiopreventive effects, male Wistar rats were orally treated with of  U. fasciata ethanolic extract and its biosynthesized AgNPs (100 mg/kg body weight; 3 times/week) concurrently with intraperitoneal injection of doxorubicin (2.5 mg /kg body weight three days/week) for 6 weeks. Renocardiopreventive effects of U. fasciata extract and AgNPs/U. fasciata were manifested by decrease in the elevated serum levels of kidney biomarkers (creatinine, urea and uric acid) and the elevated serum activities of cardiac enzymes (CK-MB, AST and LDH) together with the improvement of kidney and heart bioindicators of oxidative stress and antioxidant defense system as well as kidney and heart histological changes; the AgNPs/U. fasciata was more effective. In conclusion, U. fasciata extract and AgNPs/U. fasciata, which is more potent, could have preventive effect against doxorubicin-induced renocardiotoxicity in Wistar rats and this effect could be mediated, at least in part, via enhancement of the antioxidant defense system.

advances in animal and veterinary sciences

Characterization of Ulva fasciata Ethanolic Extract-mediated Biosynthesized Silver Nanoparticles and Evaluation of their Nephrocadiopreventive Effects in Doxorubicin-injected Wistar Rats