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| Camel mange is a real threat on camel breeding development. This paper aimed to investigate the hematological and biochemical changes in she-camels naturally infested with sarcoptic mange before and after treatment with ivermectin during 28 days and suggest new markers for its diagnosis and treatment monitoring. A total 20 she-camels were used for this purpose; 10 she-camels were apparently-healthy (control group (CG)) and the others (N=10) were naturally infested with sarcoptic mange, confirmed by the mange symptoms and skin scraping microscopic examination (diseased group (DG)). DG was treated with ivermectin 1% S/C (1ml/50 kg) + permethrine 5% topically (treated group (TG)). Blood samples were collected from CG, DG (before treatment) and from TG at 7th, 14th, 21st, 28th days post-treatment. Hematological and biochemical parameters were estimated and statistically analyzed. Ivermectin administration succeeded in restoring normal hemogram, leukogram, glucose levels and lipid profile at 14th day and total globulin, matrix metalloproteinases (MMPs), iron profile at 21st post-treatment. On the other hand, it resulted in a significant elevation (P˂ 0.05) in liver and kidney function tests and a significant (P˂ 0.05) decline in total antioxidant capacity (TAC) in TG at 7th day, but at 28th day AST, direct bilirubin and creatinine returned to normality and a slight increase in ALT, total and indirect bilirubin and urea concentrations was expressed till the study end. Serum iron (SI), ferritin, TAC, MMP-2 and MMP-9 achieved moderate to high values of area under the curve, cut off points, sensitivity%, specificity%, likelihood ratio, PPV%, NPV% and accuracy rate% in DG and TG. Conclusion: ivermectin administration in camel with scabies, has several adverse effects on liver and kidney functions tests due to oxidative stress. SI, ferritin, TAC, MMP-2 and MMP-9 may be useful indicator for camel mange and for tracking the infested animal response to the treatment proposal.

The Effect of Ivermectin Injection on Some Clinicopathological Parameters in Camels Naturally Infested with Scabies