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Alzheimer is a neurodegenerative disease, which is most prevalent in worldwide. But there is no cure for it so far. From many reasons, elevated calcium concentration is one, that has their roles in this disease, and it starts at early stages. According to studies, Ryanodine receptor(RYR) can be targeted for further studies, for early detection of Alzheimer 's disease(AD) and for therapeutic drug for treatment , since alteration in intracellular calcium concentration caused by many channel, among them one of is increase in expression of RYR, which increases the calcium flux at intracellular level. Also based on calcium induced calcium release, it activates its neighbouring RYR as well. So there is up regulation in intracellular calcium concentration, which deteriorate memory process. In addition, it affects action potential(shape)by the activation of large conductance channel, since it plays vital role in neurotransmitter release. In later stage ,apoptosis takes place (neuron cell death) which characterised by increase in memory loss,( so neural connection decreases). Further, this Alzheimer starts in hippocampus, where there significantly reduction of neuronal density, especially in CA1 neurons. This occurs at an early stage of disease. In this paper we have explored the Ryanodine and their mechanism in neuron. KeywordsAlzheimer, neurodegenerative disease, Calcium, Ryanodine receptor, calcium induced calcium release

Review on Modelling Aspect of Ryanodine Receptor in CA1 Neuron