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This study was achieved to the safety evaluation of the ashwagandha (Withania somnifera) and total phenolic acid and total flavonoids compounds were determined, as well as ABTS and DPPH radical scavenging activities assay were studied. In addition, the biological experimental and histological assay was an examination of hepatitis rats. The results observed that the ashwagandha root extract was safety due to do not evidence of toxic effect or mortality in mice. This safety from the ashwagandha root extract caused the extract had contained high amounts of phenolic and flavonoids compounds which directly role of in free radical scavenging, thus the extract from ashwagandha root is a source of antioxidant activity. At the end of biological experimental after eight weeks the results were found that the effects of ashwagandha roots extract on carbon tetrachloride CCl4-treated induced alterations in serum hepatic enzymes were decreased than control CCl4 positive and give nearly equal control negative at level 400mg/kg body weight for a rat. Moreover, the results found that the effect ashwagandha roots extract on antioxidant enzymes hepatic as glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx), and catalase (CAT) parameters showed that the ashwagandha roots extract was improvement the antioxidant enzymes. Furthermore, different concentrations extract alleviated histopathological changes in rats' liver treated with CCl4. Ashwagandha root extracts confirmed that the protection of the rats' liver CCl4induced hepatotoxicity. This influence may be due to activated, the antioxidant activities of these extracts. In recommending that the obviously results supported that the possible anti hepatic damage effect of ashwagandha root extract against CCl4-induced hepatic damage. This anti hepatic damage influence may be due to activated, the antioxidant activities

Evaluation of Ashwagandha (Withania Somnifera) and its Extract to Protecting he Liver From Damage