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In this study, the medicinal plant Aerva javanica was sequentially extracted with n-hexane, chloroform and 80% methanol using maceration technique. The anti-proliferative effect of the three extracts was assessed on two different breast cancer cell lines, MDA-MB-231 and MCF7, using MTT assay. 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity assay was used to assess the antioxidant activity of the three extracts. The result showed that the chloroform extract exerted an inhibitory effect in a concentration dependent manner on both cancer cell lines with IC50 values of 32.7 ± 0.7 μg/ml and 40.9 ± 2 μg/ml on MDA-MD321 and MCF7 respectively. 80% methanol extract exhibited cytotoxic effect on MCF7 with IC50 value of 96.6 ± 2.9 μg/ml, whereas had no cytotoxic effect on MDA-MB-231 cell line (IC50 ˃ 200 μg/ml). n-hexane extract found to be less cytotoxic against both cancer cell lines with IC50 values of 178.3 ± 3.7 and 196.9 ± 2.8 μg/ml on MDA-MB-231 and MCF7, respectively. The highest IC50 value for scavenging activity was shown by 80% methanol extract (46.5 ± 2.2 μg/ml) followed by chloroform extract (78.3 ± 3.6 μg/ml). On the other hand, the extract prepared in n-hexane showed no scavenging activity effect (IC50 ˃ 1000 μg/ml). Aerva javanica possesses moderate anti-proliferative activity against human breast cancer cell lines with some cytoselectivity towards MDA-MB-231 compare to MCF7 cells. Further studies are needed to identify the potential anticancer component (s) from Aerva javanica.

ANTI-PROLIFERATIVE EFFECT OF Aerva javanica EXTRACTS ON MCF7 AND MDA-MB-231 BREAST CANCER CELL LINES