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von Willebrand factor (vWF) is a large multimeric glycoprotein which is normally released by the brain endothelial cells and is therefore present as a circulating protein in the blood. The initial and mature structure of vWF is uncleaved; however, pneumococcal infection can cause the cleavage of the protein, thus forming

Streptococcus pneumoniae Infection Increases Expression of von Willebrand Factor (vWF) in a Mouse Brain Endothelium Model