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Oz Periodontal hastaliklar cesitli mikroorganizmalar tarafindan baslatilmis olsa da, kompleks mikroflorasi ve konak yaniti periodontal durumu etkilemekte ve sipesifik hastalik belirteclerini tanimlamayi zorlastirmaktadir. Periodontal hastalik tanisinda kullanilan sondalamada kanama, cep derinligi, klinik atacman seviyesi ve radyolojik kemik miktari gibi klinik periodontal parametreler, hastaligin siddetinin, prognozunun ve tedaviye verilen yanitin degerlendirilmesinde yetersiz kalmaktadir. Bu nedenle, diseti olugu sivisi, tukuruk ve serum oneklerinde tespit edilebilen cesitli biyobelirtecler bu konuda bize umut isigi olmaktadir. Son donemlerde, doku savunma hucreleri olan adipositlerden salinan ve adipokinler olarak adlandirilan bazi proteinler rapor edilmistir. Bu derlemede, cesitli periodontal hastaliklarda calisilmis adipokinler incelenmis ve gelecekte adipokinlerin bir biyobelirtec olarak periodontoloji alaninda uygulanabilirligi tartisilmistir. Anahtar Kelimeler: Adipokin, Yag doku, Periodontal hastalik, biyobelirtec PROMISING BIOMARKERS IN THE DIAGNOSIS AND PROGNOSIS OF PERIODONTAL INFECTION Abstract Although periodontal disease is started by various bacteria, complex microflora and the host response affects periodontal condition and makes it difficult to identify specific disease marker. Clinical parameters including such as bleeding on probing, probing depth, clinical attachment level and radiographic bone amount which used in the diagnosis of periodontal disease, are insufficient to evaluate the severity and prognosis of disease and response to treatment. Therefore, various biomarkers that can be detected in gingival fluid, saliva and serum sampels are the light of hope for us. Recently, some proteins, called adipokines, which have been released from adipocytes as tissue defense cells, have been reported. In this review, adipokines studied in various periodontal diseases are investigated and the applicability of adipokines as a biomarker in the field of periodontology is discussed. Key Words: Adipokines, adipose tissue, periodontal disease, biomarkers

PERİODONTAL ENFEKSİYONUN TEŞHİS VE PROGNOZUNDA UMUT VADEDEN BİYOBELİRTEÇLER