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Amac: Bu calismada temporomandibular eklem (TME) osteoartriti ve TME hipermobilitesi olan eriskin hastalarda dekstroz proloterapinin uzun donemde klinik etkinligi degerlendirilmistir. Gerec ve Yontem: Bu calisma, hem klinik inceleme ile hem de konik isinli bilgisayarli tomografi (CBCT) ile teshis edilen, 14 dejeneratif ve hipermobil ekleme sahip 11 eriskin hasta uzerinde yurutulmustur. 2 ml %30’luk dekstroz, 2 ml salin ve 1 ml % 2’lik artikain veya mepivakain karisimlarindan olusan 1 ml dekstroz enjeksiyonlari aylik olarak toplamda 3 seans olarak ust eklem boslugu, ust ve alt kapsuler ligament, posterior disk ligamenti ve stylomandibular ligament olmak uzere 5 ayri alana enjekte edildi. Sonuc degiskenlerini gorsel analog skala (VAS) degerlendirmeleri ve maksimum interinsizal aciklik (MIA) degerleri olusturmaktadir. Klinik degerlendirmeler, tedavi baslangicinda (T0), son enjeksiyon tedavisinden hemen sonra (T1) ve 12 ay sonra (T2) kaydedildi. Bulgular: Eklem sesi, MIA ve agri sikayetleri tedavi- den hemen sonra onemli olcude azalmistir. MIA deger- leri, tedavi sonrasi 12 aylik takip periyodunda baslangic degerlerine geri donmustur. Cigneme etkinliginde tedavi sonrasinda ve takip periyodu suresince istatistiksel olarak anlamli bir fark gorulmemistir. Sonuc: Bu calisma bulgulari, TME osteoartriti ve TME hipermobilitesine sahip semptomatik hastalarda, tekrarlayan dekstroz proloterapi enjeksiyonlarinin eklem sesi ve agri sikâyetlerinde onemli klinik iyilesmeler saglayabildigini gostermistir. Anahtar Kelimeler: Dekstroz proloterapi, TME hipermobilitesi, TME Osteoartriti AN ASSESSMENT OF CLINICAL EFFICACY OF HYPERTONIC DEXTROSE PROLOTHERAPY ON OSTEOARTHRITIC TEMPOROMANDIBULAR JOINTS ABSTRACT Aim: In this study, long-term clinical efficacy of hypertonic dextrose prolotherapy was assessed on patients with both temporomandibular joint osteoarthritis and hypermobility. Material and Method: This study was carried out on 11 adult patients, whom had 14 temporomandibular joint with both osteoarthritis and hypermobility diagnosed with clinical examination and CBCT evaluations. Participants received 1- ml injections of dextrose solution in each of the five injection areas at three sessions, each a month apart; this solution consisted of 2 ml 30% dextrose, 2 ml saline, and 1 ml 2% articaine or mepivacaine. The prepared solutions were injected into five areas according to the treatment protocol, in the following order: posterior disk attachment, superior joint space, superior and inferior capsular attachments, and stylo-mandibular ligament. The outcome variables were visual analogue scale (VAS) evaluations and maximum inter-incisal opening (MIO). Outcome variables were recorded preoperatively, immediately after injection and at 12 months postoperatively. Results: MIO, general pain complaints and joint sounds decreased significantly in after injections, but MIO returned to baseline values after 12 months postoperatively. Masticatory efficiency showed insignificant changes after injection and during 12 months follow-up period. Conclusion: Findings of the present study suggest that repeating dextrose prolotherapy may provide improvements on general pain complaints and joint sounds of the patients had both temporomandibular joint osteoarthritis and hypermobility Key Words: Dextrose prolotherapy, TME hypermobility, TME Osteoarthritis

OSTEOARTRİTİK EKLEMLERDE HİPERTONİK DEKSTROZ PROLOTERAPİNİN KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ