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Aloe vera has an inhibitory system (anti-inflammatory activity) and a stimulatory system (wound-healing activity), which may act as a modulator of wound healing and inflammation. The action mechanism of aloe vera to wound healing, inflammation, and analgesic was discussed. Aloe vera reduces pain by blocking the synthesis of bradykinin, cyclooxygenase-2, and thromboxane synthase. Furthermore we presented six case reports of Kampo medicine with successive ingestion of aloe vera juice in which Kampo medicine demonstrates to be a suitable personalized medicine for wound and improves gut-microbial ecosystem in host.

Possible Efficacy of Aloe Vera Gel to Wound Healing and Pain Relief: Case Reports of Kampo Medicine With Aloe Vera Juice