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AIM: The role of β-glucan supplementation on cancer development is well established. In this report we focused on the effects of glucan on levels of individual classes and subclasses of immunoglobulins. MATERIALS AND METHODS: We evaluated the levels of IgM, IgG, IgA, IgG1, IgG2, IgG3 and IgG4 in 39 patients diagnosed with breast or colorectal cancer. RESULTS: We found a significant decrease of IgG1 levels in the placebo group, which was particularly pronounced in females. CONCLUSIONS: Short-term glucan supplementation significantly stabilized levels of IgG1 resulting in maintaining anti-infectious immunity. The decrease in IgG1 levels found in the placebo group was clearly caused by a complex therapy of cancer disease.

Effect of β-glucan Supplementation on Levels of IgM, IgA, IgG and Its Subclasses IgG1, IgG2, IgG3, and IgG4 in Cancer Patients