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Summary Background: equine gastric ulcer syndrome (EGUS) has a multifactorial nature and it affects both the squamous and glandular mucosa of the stomach. Multiple therapeutic strategies involving large periods of medication are used to treat this condition. Objective: to evaluate the effects of administering corn oil (CO) to horses with induced gastric ulcers, and to describe the mechanism of action of the mucosal repair. Methods: fifteen horses divided into three groups were used. A combination of confinement and phenylbutazone was used during the ulcer-induction phase. After the gastroscopic evaluation and laboratory tests, animals were treated with sucralfate (SA; group I), and CO at doses of 70 and 90 mL/100 Kg (groups II and III, respectively). Gastroscopy, gastric content collection, and biopsy of the glandular mucosa were performed to analyze prostaglandin E 2 (PGE 2 ), pH, and antioxidant and oxidant parameters. Results: mild to moderate gastric lesions were induced in the glandular and non-glandular mucosa. Among the mechanisms of the treatments, reestablishment of the antioxidant parameters and inhibition of myeloperoxidase (MPO) oxidant enzyme were prominent, but PGE 2 concentration had a weak influence. Conclusion: similarly to SA, CO only had therapeutic effects in the glandular mucosa. Keywords: antioxidant-oxidant, phenylbutazone, prostaglandin, stomach. Resumen Antecedentes: el sindrome de ulcera gastrica equina (SUGE) tiene naturaleza multifactorial e involucra la mucosa escamosa y glandular. La terapeutica implica varias estrategias y periodos largos de medicacion. Objetivo: evaluar los efectos del aceite de maiz (AM) en equinos con ulcera gastrica inducida, y describir los mecanismos de reparacion de la mucosa. Metodos: quince equinos fueron utilizados en tres grupos. Para la induccion fue utilizado confinamiento y fenilbutazona. Posterior a la evaluacion gastroscopica y examenes de laboratorio los animales fueron tratados asi: el grupo control (grupo I) recibio sucralfato (SA), mientras que se administro AM en dosis de 70-90 mL/100Kg (grupos II y III respectivamente). Fueron realizadas gastroscopias, recoleccion de contenido gastrico y biopsia de zona glandular para analisis de prostaglandina E 2 (PGE 2 ), pH, parametros antioxidantes y oxidantes. Resultados: lesiones gastricas de intensidad leve a moderada fueron inducidas en las areas glandular y no glandular de la mucosa. Los principales hallazgos encontrados fueron el restablecimiento de los parametros antioxidantes, la inhibicion de la enzima oxidante mieloperoxidasa (MPO) y leve alteracion en la PGE 2 . Conclusion: el AM solo tuvo efecto terapeutico en el area glandular, similar a los efectos del SA. Palabras clave: antioxidante-oxidante, estomago, fenilbutazona, prostaglandina. Resumo Antecedentes: a sindrome de ulcera gastrica equina (SUGE), tem natureza multifatorial, atingindo ambas mucosas. A terapeutica exige varias estrategias com periodos longos de medicacao. Objetivo: avaliar os efeitos do oleo de milho (OM) em equinos com ulceras gastricas induzidas, com descricao dos mecanismos na reparacao da mucosa. Metodos: quinze equinos foram utilizados em tres grupos. Na inducao das ulceras foi utilizado o confinamento e a fenilbutazona. Apos avaliacao gastroscopica e exame de laboratorio, os animais foram tratados, o grupo controle, (grupo I), recebeu sucralfato (SA), entanto nos grupos II e III se administrou OM em dose de 70-90 mL/100 Kg. Foram realizadas gastroscopias, colheita de conteudo gastrico e biopsia da area glandular da mucosa para analise de: prostaglandina E 2 (PGE 2 ), pH, parâmetros antioxidantes e oxidantes. Resultados: lesoes gastricas de intensidade leve a moderadas foram induzidas nas areas glandular e nao glandular da mucosa. Entre os principais resultados encontrados foram o reestabelecimento dos parametros antioxidantes, a inibicao da enzima oxidante mieloperoxidase (MPO) e uma leve alteracao na PGE 2 . Conclusao: o OM so teve efeito terapeutico na area glandular similar aos efeitos do SA. Palavras chave: antioxidante-oxidante, estomago, fenilbutazona, prostaglandina.

Effects of corn oil on the gastric mucosa of horses with induced ulcer