English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aims. Aim: to improve the effectiveness of prognosis of early recurrence in patients with localised prostate cancer (PC) after radical surgery by assessment of expression of prostate-specific antigen РCА3 [prostate cancer associated 3] in the urine sediment and exosomes. Materials and methods. The study included 148 patients with localised PC. The serum level of prostate-specific antigen (PSA) was determined for all patients by enzyme immunoassay at the baseline and every 3 months after radical prostatectomy (RPE) for two years. Patients were divided into two subgroups depending on the presence or absence of biochemical recurrence (BR). Expression of PCA3 gene was determined in the urine sediment and exosomes by PCR [polymerase chain reaction] in real time, relative to the reference human kallikrein gene KLK3 [kallikrein related peptidase 3]. Results. PCA3 gene expression level in urine exosomes of patients with prostate cancer and prostatic intraepithelial neoplasia grade 2 (PIN2) was higher in the subsequent recurrence compared with a favourable course of the disease. With a decrease of ∆Ct РСА3–KLK3 to less than 1.86 inclusive in urine sediment, BR in patients with PC and PIN2 in the peritumoral area occurred more frequently (83% vs. 45%, p=0.008). Conclusions. Prognostic significance of the evaluation of РСА3 gene expression in the postmassage urine sediment and exosomes for determining BR risk after RPE in patients with localised PC is higher than the determination of PSA in the blood serum. With an increase in the PCA3 gene expression in the postmassage urine sediment and exosomes in patients with localised PC, the BR risk within two years after RPE increases.

PROGNOSIS OF THE EARLY DISEASE RECURRENCE IN PATIENTS WITH LOCALISED PROSTATE CANCER AFTER RADICAL SURGERY