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Studies have revealed a close relationship between the development of inflammatory changes in the periodontium and the activity of free radical processes (antiparticles) and antioxidant protection (AOP). Objective: to study the effectiveness of antioxidant therapy with “Antoksid” in the complex treatment of patients with chronic periodontitis of moderate severity. The task of the study was also the determination of the antioxidant activity of the developed therapeutic and dental agent “Antoksid” (Patent # 960) by the “in vitro” method. The object of the study was the shade of erythrocytes obtained from peripheral blood taken from 20 adult patients with periodontitis at the age of 30 to 39 years. It was revealed that “Antoksid” possesses antioxidant properties when exposed to pathological biological fluids, in particular, the blood plasma of patients with periodontitis. Comparative clinical studies in evaluating different treatment methods were performed in 30 patients, the control group consisted of 10 healthy people. The results of the treatment were evaluated on the 5th and 10th days of treatment. The evaluation was carried out by biochemical methods on the effect on the state of the processes of LPO, AOP systems in cell membranes (erythrocyte) and blood plasma. It was found that the best effect was achieved by treatment with the introduction of “Antioxidant” by the method of UFF, and the treatment with the traditional method was the least effective. Studies have shown that the use of “Antoksid” in the treatment of chronic generalized periodontitis leads to an increase in cell resistance to oxygen deficiency, activation of enzymatic reactions, and elimination of microcirculation disorders. Activation of the AOZ system, in turn, leads to restriction and breakage of chain radical reactions, normalization of oxidation-reduction reactions in cells and tissues, restriction of the inflammation focus and intensification of proliferative processes in periodontal tissue.

RESULTS OF USE ANTIOXIDATE THERAPY WITH “ANTOKSID” IN COMPLEX TREATMENT OF CHRONIC GENERALIZED PARODONTITIS OF MODERATE SEVERITY