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Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Pre-eclampsia associated with intrauterine growth retardation, preterm birth, maternal and perinatal death. Dyslipidaemia has been shown to play a significant role in the pathogenesis of the disease and often precede linical manifestations. Objective: To compare the serum lipid profile in pre-eclampsia case and normal pregnant women and to assess its role in pre-eclampsia. Material and Method: 158 patients of which 79 pre-eclampsia (cases) and 79 (controls) were selected randomly and were matched with their gestational age in patient who Attending ANC clinic at Department of obstetrics and genecology in March 2016 to August 2017. Lipid profile was estimated by the Randoximola is a compact fully automated clinical chemistry analyser. Result: We observed that pre-eclampsia is more common in young age pregnant women with low socioeconomic status with strenuous activities. The mean age was 24.51±3.707 years. The mean cholesterol, triglyceride, LDL,VLDL, value is analysed with control group showing significantly increase (p<0.0001) and HDL value significantly decreasedin pre-eclampsia patient in comparison to the normal control group (p<0.0001). Conclusion: Young age, nulliparity, low socio-economic status specially labour occupation, dyslipidaemic pregnant women were found to be more prone to develop pre-eclampsia. Proper history tacking, examination and estimation of lipid profile may be helpful forearly diagnosis and management of pre–eclampsia in order to prevent fetal and maternal complications especially in nulliparous women. Key wards: Pre-eclampsia, Dyslipidaemia, Blood Presser, Tertiary canter  Introduction Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension (blood pressure >140/90 mm Hg) with proteinuria (urinary protein excretion of > 300 mg in 24 hours urine) after 20 weeks of gestation in previously normotensive and nonproteinuric pregnant women. Pre-eclampsia has been associated with intrauterine growth retardation, preterm birth, maternal and perinatal eath [1]. Pre-eclampsia occurs in 7-10% of pregnancies world wide. In India the incidence is reported to be high approximate 8-10% of the pregnancies women in developed countries have an average life time risk of Manuscript received: 7 th February 2018 Reviewed: 14 th February 2018 Author Corrected: 20 th February 2018 Accepted for Publication: 26 th February 2018 dying from pregnancy related causes of between 1 in 4000 and 1 in 10000, where as women in developing countries have a risk that is between 1 in 15 and 1 in 50 [2-3]. In non interventioned, pre-eclamptic cases may progress further to the dreaded complications like; eclampsia, HELLP syndrome, pulmonary edema, abruption placentae, postpartum circulatory collapse, acute renal failure, hepatic rupture, cerebral haemorrhage and visual disturbances including death. These conditions are also a major cause of neonatal morbidity and mortality [4]. Put forward for pre-eclampsia theories like placental ischemia, genetics, immunemaladaptation and oxidative stress have been proposed. Out of which oxidative stress theory is most widely accepted and has been linked with lipid abnormalities and vascular January March, 2018/ Vol 4/ Issue 1 Print ISSN: 2456-9887, Online ISSN: 2456-1487 Original Research Article Pathology Update: Tropical Journal of Pathology & Microbiology Available online at: www.pathologyreview.in 122 | P a g e dysfunction. Predominantly atherogenic LDL (low density lipoprotein) are increased in association with hyper lipidaemia in preeclampsia [5]. This study is designed to evaluate the serum lipid profile in preeclampsia women and compared them with normal pregnant women. Material and Method Type of studycase control. Period of study1 st March 2016 to 31 Aug 2017 (1year and 6 month). Place of studyDepartment of obstetrics and Gynaecology, Netaji Shubhash Chandra Bose medical college Jabalpur. Study subjects: Total 158 patients, where 79 preeclampsia (cases) and 79 normal pregnant women in third trimester (control). Sampling method and Source of data-Patients Attending ANC clinic at Department of obstetrics and Gynaecology who fulfill the inclusion criteria were selected by simple random sampling method for study, after obtaining the written informed consent. Study variable included Demographic data, family and personal History of pre-eclampsia, hypertension, diabetes mellitusand investigations details was recorded in the study proforma. After consent 5 ml of blood was drawn under aseptic precaution from antecubital vein and collected in a EDTA and a plane tube. Lipid profile was measured using the Randoximola is a compact fully automated bench-top clinical chemistry analyser. Inclusion CriteriaAll the pre-eclampsia patient (hypertension (blood pressure > 140/90 mm Hg) with proteinuria (urinary protein excretion of > 300 mg in 24 hours urine) after 20 weeks of gestation in previously normotensive andnonproteinuric pregnant women) Exclusion criteria a) Age >35year b) Eclampsia c) Obesity d) Family history of hyperlipidaemia. e) Diabetics before pregnancy. f) Patient with known hypertension, Renal disorders, liver disorder, thyroid disease, collagen vascular disease, patient taking drugs which alters thyroid and lipid metabolism. Statistical analysisThe statistical analysis was carried out by using SPSS 20 software of windows. Appropriate univariate and bivariate analysis was carried out using Student’s t-test and chi-square testfor categorical data by a statistician. All means are expressed as mean ± standard deviation and the proportion as in percentage (%). The critical value for the significance of the results will be considered < 0.05 level.

Pre–eclampsia and dyslipidaemia a case control study: an experience of tertiary healthcare centre in central India