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Back ground: Neonatal sepsis is one of the most important causes of morbidity and mortality in children. The incidence was 3% in intramural births, with an overall mortality rate of variation of 18.6%  Aims and Objectives: To evaluate the role of blood culture, micro ESR, CBP, CRP in the diagnosis of sepsis in children. To study sensitivity, specificity, positive predictive values and negative predictive values of the above hematological parameters, either individually or in combination with diagnosis of neonatal sepsis Method: A prospective study was carried out from January 2015 to December 2015. It was cross sectional and hospital based .samples included babies having history of infective etiology with the onset within the first 28 days of birth. Result:One hundred neonatal cases of clinically suspected septicemia were included in this study. Culture positive rate was 26%. E coli was the major organism responsible for early onset of sepsis. The highest sensitivity and negative predictive value was found for septic score of more than or equal to 3 by septic scoring, I:T ratio and C- reactive protein with the highest sensitivity, micro ESR and TLC had the highest specificity.Conclusion: CRP emerged as the test with the highest sensitivity. Micro- ESR and TLC had the highest specificity.

A comparative study of CBP, CRP, Micro ESR and blood culture in the diagnosis of neonatal septicemia