English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Background: Head and Neck squamous cell carcinoma (HNSCC) is the seventh most common cancer in the world with poor overall survival rate which is unchanged during the last two decades. Aim: Aim of our study is to measure the level of Epidermal Growth Factor Receptor (EGFR) expression in HNSCC by immunohistochemistry (IHC) and to correlate EGFR with clinicopathological variables. Settings and Design: Cross sectional study from 1 st October 2012 to 31st of March 2014 was performed. Materials and Methods: After taking detailed history and a thorough examination, biopsy/ specimen of HNSCC region were evaluated to confirm the diagnosis of HNSCC. Paraffin blocks of such tumors were processed for EGFR staining. Staining intensity was evaluated by using scale from 1 to 4. Statistical Analysis: Chi-square test was used as appropriate for data analysis. Results: In the present study 38/50 (78%) patients were diagnosed as well differentiated, 12/50(24%) were diagnosed as moderately di fferentiated. For EGFR staining, 24/50 (48%) scored as +2, 16/50(32%) as +3, 8/50(16%) as +1 and 2/50(4%) scored as 0. 23/38(60.5%) well differentiat ed SCC cases presented as +2, 5/38(13.2%) as +3, 8/38(21.1%) as +1 and 2/38(5.3%) as 0. 11/12(91.6%) moderately differentiated SCC cases were scored as +3, 1/12(8.3%) as +2. p value 0.001, which is highly signifi cant. However, correlation of EGFR scoring with patients age, sex, addiction history, site of the tumor was insignificant. Conclusion: EGFR was highly expressed in HNSCC. The result of our study showed that, high EGFR scoring was associated with high grade of the tumor. There was no signi ficant rel ationship between EGFR scoring and clinicopathological variables.

EGFR scoring in head and neck squamous cell carcinoma and its association with clinicopathological variables