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Carcinoma breast is a heterogeneous malignancy with distinct age of onset pattern. Age specific incidence profile of breast carcinoma shows exponential rise until menopause and then slow after menopause. Largely early onset breast carcinoma represents inherited cause and late onset breast cancer following extended exposure to cancer promoters. Expression of ER shows gradual increase beginning in 3rd decade to a plateau by 6th decade. The present study is aimed at the correlation of expression of ER, PR with the onset of age of breast cancer, histopathological grading, size of tor and metastatic behavior. Material and Method: The study was carried out in 80 cases of invasive duct cell carcinoma. Clinicopathological findings, histopathological grading and immunohistochemistry for ER and PR expression were performed. Result and Conclusion: Majority cases (85%) of invasive duct cell carcinoma fall in 31 to 60 years of age group. Most of the patients show more than 2 cms size (90%). Majority of the patients fall in histopathological grade II (67.5%) followed by grade I (27.5%). Lymph node metastasis was seen in 45% cases in all grades. ER and PR expression show declining trend with age of onset of breast carcinoma. It reflects dysregulated ER and PR expression which contribute to the breast carcinoma etiology. Loss of ER expression result in to distinct age of onset pattern, therefore early onset breast cancer may be benefitted by hormone therapy. Metastatic behavior is independent of ER and PR expression.

international journal of medical research and review

Correlation of Expression of ER, PR with the onset age, histopathological grading, size of tumor and metastatic behavior of invasive duct cell carcinoma breast