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Thyroid hormones are important for early brain development. During pregnancy, both maternal and foetal thyroid hormones contribute to foetal brain development. Maternal Graves’ can lead to transplacental transfer of antibodies that cause neonatal thyrotoxicosis. Neonatal thyrotoxicosis is rare and a high index of suspicion is needed to diagnose it. Neonatal thyrotoxicosis has significant risk of morbidity and mortality and early recognition is warranted. Babies who are at risk following birth should be identified early while avoiding the need for unnecessary blood tests or prolonged hospital admission. There are no published consensus guidelines to date as to how these babies should be managed and followed up. The purpose of this guideline is to describe the importance of risk stratification and subsequent management of babies born to mothers with a history of Graves’ disease.

The Importance of Risk Stratification and Management of Newborn Babies of Women with a History of Graves' disease