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Back ground: Diabetes Mellitus is a public health problem associated with increased maternal blood sugar level and impair insulin secretion leading to complication of pregnancy and retarded placental development. Maternal diabetes developed premature term and mortalities of their child. The alterations of placental spiral artery during the progress of diabetes paid attention and little of work is concerned with this public health problem. The traditional increase of phytotherapy especially pomegranate peel extract and bee venom therapy encourage author to carry out this study in spiral artery of placenta at 14days of pregnancy in order to clarify the best choice of improvement the histological picture of the spiral artery.

The potential effects of pomegranate peel extract and bee venom in improving the diabetes induced damaging of spiral artery