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Secondary degeneration after ischemic stroke has been demonstrated by computed tomography and magnetic resonance imaging. We report a 77-year-old man with striatal infarction followed by multifocal degeneration that developed in a stepwise manner at the ipsilateral substantia nigra and thalamus on diffusion-weighted images obtained at 4 weeks, 6 weeks and 20 weeks after onset. We also review the underlying pathophysiology and its clinical meanings. J Korean Neurol Assoc 36(3):203-206, 2018

Secondary Degeneration of the Ipsilateral Thalamus and Substantia Nigra Following Cerebral Infarction in the Striatum