English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: The aim of this study was to investigate the association between the +781C/T polymorphism in the inter leukin-8 (IL-8) gene and the acute neurological recovery and 3-month outcome of atherosclerotic cerebral infarction patients in the Han Chinese population. Methods: We investigated the +781C/T polymorphism of IL-8 in 308 consecutive Han Chinese patients who were diagnosed with an atherosclerotic cerebral infarction. The neurological recovery of the patients were evaluated by the difference of National Institute of Health Stroke Scale (NIHSS) score for the acute stage of the stroke and the Barthel Index (BI) score at 3 months after the stroke. Polymorphic genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: We found that the +781C/T genotypes of IL-8 were significantly associated with neurological recovery after cerebral infarction (p = 0.045), and a significant difference in the neurological recovery of the patients was found between patients with the CT genotype and TT genotype (mean difference: 2.934, p = 0.040). No statistically significant association was found between the +781C/T polymorphism with the 3-month BI scores obtained after cerebral infarction (p = 0.416). Conclusion: Our results demonstrated that the +781C/T polymorphism of IL-8 is associated with neurological recovery at the acute stage of atherosclerotic cerebral infarction in the Han Chinese population, and the patients with the CT genotype recovered better than those with other genotypes. However, no association was found between the +781C/T polymorphism and the 3-month outcome of cerebral infarction patients.

journal of neurophysiology and neurological disorders

An association study between the +781C/T polymorphism in the interleukin- 8 gene and the neurological recovery and prognosis of atherosclerotic cerebral infarctions