English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

School-aged children and their health conditions, in particular, deficient conditions are not less note worthy than in younger children, while the recognition of present low vitamin D provision in children of all age groups has not still resulted in implementation of mass prophylaxis of hypovitaminosis D. There are several factors on which blood concentration of 25 (OH) D—calcidiol-depends. However, it is evident that among numerous factors we should orient on several most significant and develop correction scheme for the deficient condition in every region. Aim: to assess vitamin D levels in adolescents residing in Moscow, to correct their calcidiol status based on a baseline blood concentration of the transport metabolite. Materials and methods: 769 adolescents aged 11-18 years were examined and their blood concentration of 25 (OH) D was determined. Then, 218 patients were randomized to 2 groups: the treatment group received food supplement “Minisun Vitamin D3” in tablets, the control group received placebo. Cholecalciferol dosage was prescribed depending on the baseline calcidiol level in patients. The study continued for 6 months, after that blood was re-withdrawn for calcidiol level. Results: low calcidiol provision was observed among school children: median 25 (ОН) D was 16.3 [11.4-20.8] ng/mL, only 5.2% of patients had normal blood concentration of calcidiol. There-examination showed significant differences in vitamin D status in the treatment and control group, in the meantime, during cholecalciferol supplementation, median 25 (OH) D in patients of the treatment group was increased from 16.2 [12.25-19.3] ng/mL to 24.2 [21.05-26.4] ng/mL (p < 0.001). Conclusions: the larger part of child population—70.6% has 25 (OH) D concentration < 20 ng/mL, cholecalciferol doses used in the study allow eliminating calcidiol deficiency and overcome the boundary of 20 ng/mL, but for normalization of vitamin D status in blood of adolescents residing in Moscow higher dosages shall be used which is to be confirmed by further studies.

Efficacy of Hypovitaminosis D Correction in Children of the Older Age Group Residing in Moscow