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The active metabolite of vitamin D activates macrophages and results in the restriction of growth of Tuberculosis (TB) pathogen M. tuberculosis. The effect of vitamin D is achieved through binding to the Vitamin D Receptor (VDR), which ultimately produces the antimicrobial peptide Cathelicidin. Matched case-control study with 76 pulmonary tuberculosis Indonesian Batak ethnic patients and 76 healthy normal control were completed. Genetic polymorphisms of VDR gene were analysed using PCR and RFLP. The genotype frequencies of ApaI were AA 10.6%, Aa 44.7%, aa 44.7% for the control group and AA 10.6%, Aa 43.4%, aa 46% for the PTB patients. For the FokI genotype the frequencies were FF 39.5%, Ff 44.7%, ff 15.8% for the control group and FF 35.5%, Ff 55.3%, ff 9.2% for the PTB patients. In these two genotypes there were no significant differences found between the control group and the PTB patients (P > 0.05). Besides, there genotypic frequencies were in agreement with the Hardy-Weinberg Equilibrum (P > 0.05). However, for the BsmI genotype frequencies, BB 2.6%, Bb 23.7% and bb 73.7% for the control group and BB 0%, Bb 68.4%, bb 31.6% for the PTB patients, there was a significant association found with PTB; the bb genotype is correlated with a decreased risk for PTB (OR 0.22, 95% CI: 0.11-0.45). ApaI and FokI polymorphisms of VDR gene do not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Indonesian Batak ethnic population but BsmI polymorphism had association with host resistant to PTB.

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis?