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Avocado (persea americana) has antioxidant, anti inflammatory, anti obesity, anticancer effects. The effect of AVOE (avocado extract) on liver TNF-α(tumor necrosis factor-α), COX-2 (cyclooxygenase-2), LOX (lipoxygenase), caspase-3, DNAF (DNA fragmentation), NO (nitric oxide), MDA (malondialdehyde), TP (total protein) as well as serum lipid profile and liver functions in rats treated and untreated with DEN (diethyl nitrosamine) was studied. The levels of TNF-α, COX-2, LOX, caspase-3, DNAF, NO, MDA, TP as well as serum lipid profile and liver functions showed an elevation in rats treated with DEN as compared to control. Treatment of rats with AVOE pre, during, and post DEN administration improved TNF-α, COX-2, LOX, caspase-3, DNAF, NO, MDA, TP levels as well as serum lipid profile and liver functions as compared to DEN, indicates that AVOE reduced oxidative stress, inflammation and apoptosis induced by DEN. Treatment of healthy rats with AVOE only for 30 days not induced oxidative stress, inflammation and apoptosis for normal liver tissues.

Study on the Effect of Avocado on Apoptosis, Oxidative Stress and Injuries Induced by Diethyl Nitrosamine in Rat Liver