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Our previous studies on the formalin pain model have shown that halogen polarized light converted by fullerene produces a significant antinociceptive effect. It was installed for applications on the locus of pain or acupuncture points (AP). Our goal was to study the characteristics of analgesic reactions of animals under the influence of different wavelength ranges of halogen and fullerene light and to identify the contribution of fullerene component in reducing inflammatory pain depending on the spectrum, power density and illuminance. Methods: The experiments were performed on mice with an artificially created locus of inflammatory somatic pain (formalin test). The light source was Bioptron-MedAll device equipped with a halogen lamp. In separate series (80 animals in total) we studied the effect of light transmitted through fullerene filters (based on CR39 or PMMA) on the pain intensity and non-painful behavioral reactions when it was applied to the pain locus or to the AP E-36. Analgesic effects were compared with data obtained under the action of polychromatic (480+ nmand 320+ nm) light or 3 placebo light options, taking into account physical characteristics of the filters. Results: It was found that fullerene light gave the best analgesic effect regardless of the type of filter substance (PMMA or CR39). When fullerene light (CR39 filter) was applied to the pain locus, analgesia was 34.3%. An analgesic reaction was also detected during its action on the AP E-36, 32.6%, while the halogen polychromatic light was weaker (16.2%). The light passing through the fullerene+PMMA filter when applied to the pain locus alleviated pain by 29.8%. Polychromatic light application produced analgesia of 480+ nm was 23.2%, and 320+ nm, 14.4%. All placebo variants were less effective, although analgesia also occurred: 25.3% (CR39 fullerene free), 24.9% (PMMA fullerene free), and 27.7% (color copy of fullerene filter spectrum). The biological effectiveness of the studied light variants, estimated by the intensity of pain syndrome, correlated mostly with the power density and the wavelength range of light. Fullerene filters convert PL almost in the same way, with a similar analgesic result, but the biological effect of fullerene+CR39 light is more noticeable. Conclusion: Fullerene modified light, compared to halogen, has the greatest analgesic efficacy against formalin-induced pain. This result is achieved by the sorption of frequencies of the blue part of the spectrum by fullerene and depression of the power of the visible spectrum as a whole.

journal of us-china medical science

Innovative Light Therapy: 2. Determination of the Biological Contribution of Fullerene, as a Converter of Polarized Light, on a Model of Formalin-Induced Pain