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The study aims to investigate the relationship of genotypes and dynamics of drug resistance of MBT (Mycobacterium Tuberculosis) in North-West territories. Patients with pulmonary tuberculosis from areas with similar epidemical situation but different trends were selected using random sampling technique: the first group—90 patients from the Pskov region, and the second—90 patients from the Kaliningrad region. Genotyping of Mycobacterium tuberculosis strains was performed by test system of CJSC “Syntol” Russia “Amplitub-Beijing”. Drug sensitivity of MBT was determined by the method of absolute concentrations on Lowenstein medium. The frequency of determination of MBT Beijing family is found equal in 45.6% of cases in the Pskov and Kaliningrad regions. Excretion of drug-resistant MBT in the Pskov region was higher (61.1%) than that in Kaliningrad (45.6%). Beijing strains identified in similar high proportion of drug resistance (85.4% and 80.5%), including MDR (multidrug resistance) (58.5% or 65.9%) in the territories. Among “not Beijing” family strains in the Pskov region drug resistance was in 40.8%, which is 2.5 times more than that in Kaliningrad region (16.3%, P < 0.01). More significant differences are obtained in MDR cases: 32.7% and 6.1%, P < 0.001. MBT Beijing family dominates in the Northwest and growth of DR (drug resistance) and MDR of MBT is mainly due to this family MBT. But “not Beijing” strains also significantly often acquire drug resistance. Along with the MBT genotype, the differences in the epidemiological trends may be associated with problems in TB treatment organization.

journal of us-china medical science

Study of relationship between Mycobacterium tuberculosis Beijing Family and epidemiological characteristics of Tuberculosis in the northwestern region of Russia