English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

COX2  Celecoxib     ......  :   ,      .         .   COX2   celecoxib        .         ,       celecoxib    celecoxib   .  : 30        celecoxib (1, 10, 100, and 300 mg/kg)    30  12  ,   ,    .    30, 60, 120, 180  von Frey, , Hargreaves    . :   5  celecoxib   ,    ,      (P > 0.05).  celecoxib       (P > 0.05).  : celecoxib           ,      .          celecoxib    . (JKDSA 2008; 8: 29~34)   : , Celecoxib, Cyclooxygenase-2, ,  Corresponding author: Hyun Jeong Kim, Department of Dental Anesthesiology and Dental Research Institute, Seoul National University School of Dentistry 28 Yeongeon-dong Jongno-gu, Seoul 110-768, Korea Tel: +82-2-2072-3042, Fax: +82-2-766-9427 E-mail: dentane@snu.ac.kr INTRODUCTION Neuropathic pain, characterized by spontaneous pain, hyperalgesia and allodynia, includes a multiplicity of causes (Jensen et al, 2001). To date, a lot of researches have been carried out to develop the useful animal models that can dependably give rise to a neuropathic pain-like syndrome in rodents and indicate an analgesic efficacy in human clinical approaches. For examples, chronic constriction injury (Bennett and Xie, 1988), partial sciatic nerve ligation (Seltzer et al, 1990), spinal nerve ligation (Kang et al, 2005), and lately the spared 30 : 8   1  2008 nerve injury (Bourquin et al, 2006; Decosterd and Woolf, 2000), have been developed. Among diverse theories that describe the mechanisms of neuropathic pain, the close correlation between inflammatory responses and neuropathic pain states has been suggested (Bingham et al, 2005; Broom et al, 2004; Frisen et al, 1993; MacPherson, 2002; Tracey and Walker, 1995). Especially, local upregulation of cyclooxygenase 2 (COX2) at the lesion of peripheral nerve injury and the following release of prostaglandin E2 (PGE2) is closely related toperipheral sensitization, acting to change the threshold and excitability of the nociceptor peripheral terminal (McCleskey and Gold, 1999; O'Banion, 1999). On the other hand, COX2 mRNA expression is noticeably increased in the spinal cord after the injection of peripheral inflammatory stimuli such as complete Freund’s adjuvant (CFA) (Hay et al, 1997) and carrageenan (Ichitani et al, 1997), which means that the increase of COX2 mRNA in the spinal cord is involved in inflammatory allodynia and hyperalgesia and implies that some of the analgesic effect of COX2 inhibitors are not peripheral but central (Hay et al, 1997; Samad et al, 2001; Tegeder et al, 2001; Yaksh et al, 2001; Yamamoto and Nozaki-Taguchi, 1997). Also, COX2 protein levels in the dorsal spinal cord and thalamus (but not in the ventral spinal cord, cingulate cortex and locus coeruleus) increased significantly one day after nerve ligation, compared with those in the sham animals (Zhao et al, 2000). There have been lots of researches showing that COX2 plays a pivotal role in producing inflammatory pain. However, when it comes to in neuropathic pain models, the role of COX2 is still unclear because of various experimental settings. Therefore, the present study was carried out to evaluate the effectiveness of the selective COX2 inhibitor, celecoxib (Celebrex R ), on the long maintained neuropathic nociception evoked by spinal nerve ligation using behavioral tests including von Frey, cold, and Hargreaves’ test, together. MATERIALS AND METHODS

Effect of Celecoxib, a Cyclooxygenase-2-specific Inhibitor, has no Effect on Chronically Maintained Neuropathic Pain in Rats