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An eight year-old mixed breed dog was referred for evaluation with chronic sneezing, epistaxis and nasal bone deformation. A clinical exam revealed a deformity of the left nasal bone. Cytological evaluation of the nasal cavity showed round and cuboid cells in different stages of maturation. Computed tomography images identified a diffuse soft tissue mass in the nasal cavity. The histopathological diagnosis was transitional cell car - cinoma. Chemotherapy with cisplatin and piroxicam was initiated. Computed tomography was used to follow the chemotherapy outcome. As many nasal carcinomas express COX-2, its expression was evaluated before and after chemotherapy. Computed tomography revealed a significant reduction of the tumour mass. Inmunohistochemistry showed a marked decrease in COX-2 expression and after 1120 days, the dog remained without clinical signs. Thus, the use of piroxicam and cisplatin is revealed to be effective in the treatment of a nasal transitional carcinoma in a dog. Also, it is possible to postulate that a decrease in COX-2 expression after chemotherapy may be regarded as an indication for a good response to the treatment and favourable outcome. To the authors' knowledge this is the first report that evaluates COX-2 expression after chemotherapy.

Cox-2 expression after chemotherapy in a canine nasal transitional cell carcinoma: a case report