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The authors focused on the amplification of data on the mutagenicity of selected trichothecene mycotoxins (T-2 toxin, vomitoxin) and their combination with aflatoxin B 1 ,which is known to be a strong mutagen. Mutagenic activity was investigated using the Ames test in a prokaryote model at low doses (close to 0.1 LD 50 ). Whereas the individual trichothecene mycotoxins (T-2 toxin, vomitoxin) did not show any mutagenic activity in the test systems mentioned, in combination with AFB 1 , or as a combination of all three mycotoxins, they showed a mutagenic effect significantly greater than AFB 1  alone in the Ames test (in strain TA98 at all concentrations) as well as in the micronucleus test (combination of T-2 toxin with AFB 1 ).

Mutagenic effects of selected trichothecene mycotoxins and their combinations with aflatoxin B<sub>1</sub>