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Antioxidants with 1,4-dihydropyridine structure were investigated as a less harmful alternative to synthetic phenolic antioxidants in liposomes under conditions simulating food storage. The antioxidant activities (AOA) of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines possessing various side chain length alkyls (CH 3 &amp;nbsp;- C 16 H 33 ) in ester moiety were tested in transition metal-ion catalyzed liposome peroxidation and compared with AOA of Trolox&amp;trade; and Probucol&amp;trade;. The compounds with C 2 H 5&amp;nbsp; - C 4 H 9 &amp;nbsp;residues in the 3,5-position ester moieties exert the most pronounced AOA. The AOA of tested compounds is associated with their ability to incorporate into liposomes.

Antioxidant activity of 2,6-dimethyl-3,5-dialkoxycarbonyl-1,4-dihydropyridines in metal-ion catalyzed lipid peroxidation