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Progesterone (P 4 ) decreases oxytocin (OT)-stimulated prostaglandin (PG)F 2α , but not PGE 2 secre- tion from bovine endometrial cells and this effect is partly elicited via a non-genomic route. The aim of this study was to determine whether P 4 and pregnenolone (P 5 ), in the presence or absence of OT, influence: (a) the gene expression of enzymes responsible for PG s synthesis: cyclooxygenase-2 (COX-2), synthase of PGF 2α (PGFS) and PGE 2 (PGES), (b) protein expression of COX-2, PGFS and PGES, and (c) P 4 receptor membrane component 1

Genomic and non-genomic effects of progesterone and pregnenolone on the function of bovine endometrial cells