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Heat shock protein 27 (HSP‑27) is a member of the small-molecular-weight HSP family, the expression of which is increased when cells are exposed to elevated temperatures or any other kinds of stress; it seems that the cellular protective properties this protein demonstrates might also help cancer cells stay immortal. Family members of HSPs are either expressed continuously or controlled inductively, and are present in different subcellular structures.

Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma