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Fibroblast growth factor (FGF) plays a critical role in bone growth; FGF-2 is known to be an important regulator of osteoblast activity because it stimulates osteoblast replication and decreases differentiation markers. Bone morphogenetic protein-2 (BMP-2) has been shown to be an active inducer of osteoblast differentiation and stimulates expression of mineralization-associated genes.

advances in clinical and experimental medicine

Effects of the Combination of Fibroblast Growth Factor-2 and Bone Morphogenetic Protein-2 on the Proliferation and Differentiation of Osteoprecursor Cells