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are mined along a 550 km long geological feature known as the Great Dyke. The major PGM mining and concentrator operators are Zimplats, Mimosa, and Unki mine. The platinum group element (PGE), nickel (Ni), and copper (Cu) mineralization is restricted to the Main Sulphide Zone (MSZ) (Oberthur, Muller, and Lodziak, 1999). The Great Dyke is divided into two magma chambers: the North and South chambers. The magma chambers are further divided into the Musengezi and Hartley complexes, and these are divided into the Dwarendale and Sebakwe sub-chambers and Selukwe and Wedza complexes, respectively (Prendergast, 1988). The Great Dyke is generally said to be comprised of a lower ultramafic sequence (chromite, dunites, pyroxenites, and related cumulates) and an upper mafic sequence consisting of plagioclase-rich rocks (mainly gabbros, norites, gabbronorites, and olivine gabbros) (Prendergast, 1990). The primary collector used in ore flotation is xanthate. A depressant is added to suppress naturally floating gangue minerals. Optimization of reagents has been traditionally performed by varying one while keeping the others fixed. This method ignores interaction effects among reagents. Changes in reagent dosage to achieve a particular outcome may have secondary effects that override the desired effect, hence interactions have to be well understood if optimization is to be achieved. Little work has been reported on the flotation performance of Great Dyke ore. Nashwa (2008) reported on the effect on SIBIX and SIBIX-TTCs blends, but most of the work that has been reported is based on Bushveld Complex ore. Interaction effects between aeration rate and froth have been reported by Venkatesan and Harris (2014). The work showed that interaction effects were significant at conditions of high air flow rate (40 m/s ) and cell level (max. 95 % cell level). In other work based on UG2 ore, McFadzean and Pani (2015) reported on interactive effects between depressant, frother, froth height, and superficial air velocity. They reported that among the process parameters, superficial air velocity had the dominant effect on chromite and PGM recovery, while depressant had a dominant effect only on chromite grade. In this research, the interactive effects of depressant and frother were investigated while collector dosage was held constant. A twofactor analysis with six levels was done so as to observe the individual and interactive effects of frother and depressant on 4E (platinum, palladium rhodium, plus gold) recovery, grade, mass pull, and water recovery using PGM-bearing ore from the Great Dyke. Effect of frother and depressant interaction on flotation of Great Dyke PGM ore