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Objective. To investigate the effect of pre-exercise glutamine supplementation and the influence of a prior acute bout of glycogen-reducing exercise on the general stressand immune response to acute high-intensity cycling. Design. Randomised, double-blind, cross-over supplementation study.Setting and intervention. Subjects performed a series of 4 simulated mountain-bike races lasting ≈60 minutes each on separate days 1 week apart, with/ without prior glycogen-reducing exercise on a known outdoor course with/ without pre-exercise glutamine supplementation. Blood samples were collected pre- and immediately post-exercise after each race. Main outcome measures. Circulating concentrations of cortisol (COR) and dehydroepiandrosterone-sulphate (DHEAS) were assessed at all time points, as well aschanges in white blood cell (WBC) subpopulation distribution. Results. COR was elevated in all groups post-exercise (p South African Journal of Sports Medicine Vol. 18 (4) 2006: pp. 122-128

Mountain bike racing - the influence of prior glycogen-inducing exercise and glutamine supplementation on selected stress and immune parameters